The Texas Historical Commission (THC) has honored Medical City Weatherford as a historically significant part of Texas history with a Recorded Texas Historic Landmark designation.

Prior to 1945, extremely limited hospital service was available in Parker County. E.D. Fyke, MD, operated a private hospital from a converted house, known as the Colonel Bowie home. In 1945, Parker County purchased Dr. Fyke's hospital and it became known as Parker County Hospital.

As the community grew, so did the medical needs. Several remodeling phases and expansions were completed on the original structure, which was renamed in 1958 as Campbell Memorial Hospital in memory of Dr. W.M. Campbell, an early day general practitioner in the county.

In 1968, the Hospital District purchased a 35-acre tract of land and construction began on a more modern facility. On November 9, 1972, Campbell Memorial Hospital opened a 97-bed facility, now known as Medical City Weatherford.

In 2017, the facility was purchased by Medical City Healthcare, one of the region's largest and most comprehensive health care providers, further expanding its network of excellent care to Parker County residents.

Throughout the years, the hospital has collaborated with the Parker County Hospital District, multiple generations of physicians, nurses, volunteers and local partners to meet the unique healthcare needs of the surrounding community.